Recent News

	(08/05/09) Dartmouth has received a $3 million grant from the National Science Foundation for research to develop secure and trustworthy computing systems for healthcare settings. Read more here.
	(07/10/09) Prof. Amit Chakrabarti was selected as the 2009 recipient of the Karen E. Wetterhahn Memorial Award for Distinguished Creative or Scholarly Achievement.
	(06/10/09) We are pleased to announce the winners of the 41st Annual John G. Kemeny Computing Prize for Excellence in Undergraduate Computing.

Recent Technical Reports

• September 2009: Katana: A Hot Patching Framework for ELF Executables
• October 2010: Detecting Photographic Composites of Famous People
• September 2009: Activity-Aware Electrocardiogram-based Passive Ongoing Biometric Verification
• August 2009: Semantic and Visual Encoding of Diagrams
• July 2009: Distributed Monitoring of Conditional Entropy for Network Anomaly Detection

Featured Research

Family-Based Protein Design

Prof. Chris Bailey-Kellogg

Family reunions can be very interesting. Proteins have relatives (across organisms and even within the same organism) that are similar, but also different in significant ways. For example, shown in the figure are one serine protease (blue; function is to chop up other proteins) and one of its inhibitors (red; function is to block the chopping mechanism, as shown). Different proteases recognize different places to chop, while different inhibitors have different degrees of inhibition for different proteases. We are developing techniques to learn from nature's exploration of these families -- generalizing common features of observed family members and characterizing their differences, and relating these to experimental observations about their functions. This enables us to optimize our own new variants with desired functions (e.g., particularly strong and protease-specific inhibitors).

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